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The positive reinforcement effects of nicotine reflect nicotine's inherently rewarding effects that increase the probability of continued self-administration, and for both, the initiation and maintenance of tobacco use ( The National Institute of Drug Abuse (NIDA) reports that tobacco use is established primarily during adolescence, and evidence suggests that around 50% of those who start smoking in the adolescent years continue to smoke for 1520 years ( Adolescence is a period of transition characterized by significant hormonal, psychosocial, and neural changes ( E-cigarettes have emerged as the most common mode of nicotine delivery among youth across the U.S and its use is most prevalent among adolescents' and by vaping nicotine products, adolescents' do not have an awareness and understanding of nicotine and its presence within E-cigarettes products ( Smoking prevalence is a function of multiple parameters, such as initiation, cessation and relapse

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Data Availability: All relevant data are within the manuscript and its Supporting Information files

And while West Virginia topped the list of smokers, neighbor Virginia produces more tobacco but has fewer smokers

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